Padmanabhan Priya, McCullough Andrew R
New York University School of Medicine, Department of Urology, 150 East 32 Street, New York, NY 10012, USA.
J Androl. 2007 Mar-Apr;28(2):223-8. doi: 10.2164/jandrol.106.001313. Epub 2006 Oct 4.
It is believed that a chronic state of corporal oxygen desaturation or hypoxemia secondary to the loss of nocturnal erections is a fundamental pathophysiological cause of erectile dysfunction (ED). Limited invasive blood gas measurements in human models have shown decreased oxygen tension in vasculogenic impotence. Normative data on flaccid and erect oxygen saturation (StO(2)) levels are lacking due to the invasive nature of blood gas determinations. Our objective was to determine StO(2) in the flaccid and erect penis in men with and without ED using a tissue oximeter. This FDA-approved instrument provides instantaneous, noninvasive, painless local tissue StO(2) measurements, which highly correlate to blood gas data. The study population included 171 men (18-90 years) who presented to one andrologist. They completed the Sexual Health Inventory for Men (SHIM) based on pharmacologically unassisted erectile function and had penile StO(2) measurements taken. 64 of these men had repeat measurements after PGE-1 induced erections. There are significant differences (P<.001) in corporal and glanular StO(2) in the flaccid (right corpora, 45.23%; left corpora, 52.50%) and erect state (right corpora, 76.58; left corpora, 80.42). Men with ED (right corpora, 45.04% vs 53.58%; P=.02; and left corpora, 50.95% vs 58.78%; P=.03) have significantly lower corporal penile StO(2). Future prospective data collection can correlate penile StO(2) in specific populations, such as diabetics and RRP patients. This may help further elucidate the relationship between corporal hypoxia and the development and progression of ED and possibly its treatment and prevention.
据信，夜间勃起功能丧失继发的身体氧饱和度降低或低氧血症的慢性状态是勃起功能障碍（ED）的一个基本病理生理原因。在人体模型中进行的有限侵入性血气测量显示，血管性阳痿患者的氧分压降低。由于血气测定具有侵入性，因此缺乏关于疲软和勃起状态下氧饱和度（StO₂）水平的规范数据。我们的目标是使用组织血氧计测定有ED和无ED男性疲软和勃起阴茎的StO₂。这种经美国食品药品监督管理局（FDA）批准的仪器可提供即时、无创、无痛的局部组织StO₂测量，其与血气数据高度相关。研究人群包括171名男性（18 - 90岁），他们就诊于一位男科医生。他们基于药理学辅助的勃起功能完成了男性性健康量表（SHIM），并进行了阴茎StO₂测量。其中64名男性在前列腺素E - 1诱导勃起后进行了重复测量。疲软状态（右侧海绵体，45.23%；左侧海绵体，52.50%）和勃起状态（右侧海绵体，76.58；左侧海绵体，80.42）下海绵体和龟头的StO₂存在显著差异（P <.001）。患有ED的男性（右侧海绵体，45.04%对53.58%；P =.02；左侧海绵体，50.95%对58.78%；P =.03）的海绵体阴茎StO₂显著更低。未来的前瞻性数据收集可以关联特定人群（如糖尿病患者和根治性耻骨后前列腺切除术患者）的阴茎StO₂。这可能有助于进一步阐明海绵体缺氧与ED的发生、发展及其治疗和预防之间的关系。
