Carrascosa Antonio, Vicens-Calvet Enric, Yeste Diego, Espadero Rosa M, Ulied Angeles
Children's Hospital Vall d'Hebron, Autonomous University of Barcelona, Spain.
Pediatr Endocrinol Rev. 2006 Sep;4(1):15-27.
Postnatal growth was evaluated in a cross-sectional study of 486 Spanish children, 241 girls and 245 boys, born small for gestational age (SGA), without height catch-up growth between the ages of 2 and 8 years [height <-2SD of age- and sex-matched controls born appropriate for gestational age (AGA)]. SGA was defined as birth weight and/or length values <-2SD of those of the born AGA control population. Weight and height values were grouped in 0.5+/-0.15-year intervals from birth to adult height and compared with those of age- and sex-matched controls born AGA. A total of 1,985 height measurements were recorded in girls and 2,113 in boys. Adult or near-adult height was reached in 50 girls and 42 boys. Mean, SD and mean Z-score values at each age interval were calculated. Dysmorphic syndromes and chronic illnesses were excluded.
Mean height Z-score values ranged from -5.56 to -3.12 during the first two years of life and remained between -5.25 and -2.42 thereafter until adult height, and mean weight Z-score values ranged from -3.66 to -2.26 from birth to two years of age and remained between -3.05 and -0.94 thereafter until adult height. Mean Z-score values of near-adult or adult height were -2.83 in girls (n=50) and -2.74 in boys (n=42). Midparental adult height corrected for sex was -1.45 +/- 0.5 in girls (n=150) and -1.60 +/-0.6 in boys (n=185). Height +2SD values of SGA children were similar to -2SD values of age- and sex-matched AGA controls (non statistically significant).
Our data show that short children born SGA are shorter than children born AGA from the age of two years onwards and that their adult height is below that of their corresponding midparental height by more than 1 SD.
在一项横断面研究中，对486名西班牙儿童进行了产后生长评估，其中241名女孩和245名男孩，均为小于胎龄儿（SGA），在2至8岁之间身高未出现追赶生长[身高低于同年龄、同性别的适于胎龄儿（AGA）对照人群身高的-2标准差]。SGA定义为出生体重和/或身长值低于AGA对照人群的-2标准差。将体重和身高值按从出生到成人身高每0.5±0.15年的间隔进行分组，并与同年龄、同性别的AGA出生对照人群进行比较。女孩共记录了1985次身高测量值，男孩记录了2113次。50名女孩和42名男孩达到了成人或接近成人身高。计算了每个年龄间隔的平均值、标准差和平均Z评分值。排除了畸形综合征和慢性疾病。
在生命的头两年，平均身高Z评分值范围为-5.56至-3.12，此后直至成人身高一直保持在-5.25至-2.42之间；从出生到两岁，平均体重Z评分值范围为-3.66至-2.26，此后直至成人身高一直保持在-3.05至-0.94之间。接近成人或成人身高的平均Z评分值，女孩（n = 50）为-2.83，男孩（n = 42）为-2.74。校正性别的父母平均成人身高，女孩（n = 150）为-1.45±0.5，男孩（n = 185）为-1.60±0.6。SGA儿童的身高+2标准差与同年龄、同性别的AGA对照人群的-2标准差相似（无统计学意义）。
我们的数据表明，SGA出生的矮身材儿童从两岁起就比AGA出生的儿童矮，且他们的成人身高比相应的父母平均身高低超过1个标准差。
