Mayer Björn, Erdmann Jeanette, Schunkert Heribert
Universitätsklinikum Schleswig-Holstein (UKSH), Ratzeburger Allee 160, Campus Lübeck, Medizinische Klinik II, 23538 Lübeck, Germany.
Clin Res Cardiol. 2007 Jan;96(1):1-7. doi: 10.1007/s00392-006-0447-y. Epub 2006 Oct 10.
A positive family history is frequently reported by patients with coronary artery disease (CAD) or myocardial infarction. For risk stratification, it is crucial to distinguish between accidental reoccurrence of sporadic cases and cases with a true heritable component of the conditions. A familial predisposition is assumed when a myocardial infarction is diagnosed by a male first degree relative before the 55th year of life or a female first degree relative before the 65th year of life. The current manuscript reviews major studies from which a familial risk of CAD or myocardial infarction can be inferred. Moreover, a brief overview summarizes the current results of molecular genetic research on chromosomal loci and genes relevant for CAD and myocardial infarction.
冠心病（CAD）或心肌梗死患者经常报告有阳性家族史。对于风险分层而言，区分散发病例的偶然复发和具有该疾病真正遗传成分的病例至关重要。当男性一级亲属在55岁之前或女性一级亲属在65岁之前被诊断出心肌梗死时，则假定存在家族易感性。本手稿回顾了一些主要研究，从中可以推断出CAD或心肌梗死的家族风险。此外，简要概述总结了目前关于与CAD和心肌梗死相关的染色体位点和基因的分子遗传学研究结果。
