FK506：20世纪90年代的一种免疫抑制剂？
FK 506: an immunosuppressant for the 1990s?
作者信息
Macleod A M, Thomson A W
机构信息
Department of Medicine and Therapeutics, University of Aberdeen Medical School, UK.
出版信息
Lancet. 1991 Jan 5;337(8732):25-7. doi: 10.1016/0140-6736(91)93341-6.
PMID:1702172
Abstract
The novel macrolide immunosuppressant FK 506 is a powerful and selective anti-T-cell agent which has a similar mode of action to that of cyclosporin. Clinical studies of FK 506 in liver allograft recipients indicate a lower risk/benefit ratio than with cyclosporin, and wider evaluation of FK 506 in transplant recipients is now under way in multicentre, prospective, controlled trials in both Europe and North America.
摘要
新型大环内酯类免疫抑制剂FK 506是一种强效且具有选择性的抗T细胞药物，其作用方式与环孢素相似。对肝移植受者使用FK 506的临床研究表明，与环孢素相比，其风险/效益比更低。目前，欧洲和北美的多中心、前瞻性对照试验正在对FK 506在移植受者中的应用进行更广泛的评估。
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