World Cameron J, Yamawaki Hideyuki, Berk Bradford C
Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY, USA.
J Mol Med (Berl). 2006 Dec;84(12):997-1003. doi: 10.1007/s00109-006-0109-6. Epub 2006 Oct 5.
The thioredoxin (TRX) system (TRX, TRX reductase, and NADPH) is a ubiquitous thiol oxidoreductase system that regulates cellular reduction/oxidation (redox) status. The impairment of cell redox state alters multiple cell pathways, which may contribute to the pathogenesis of cardiovascular disorders including hypertension, atherosclerosis, and heart failure. In this manuscript, we review the essential roles that TRX plays by limiting oxidative stress directly via antioxidant effects and indirectly by protein-protein interactions with key signaling molecules such as thioredoxin interacting protein (TXNIP). TRX and its endogenous regulators may represent important future targets to develop clinical therapies for diseases associated with oxidative stress.
硫氧还蛋白（TRX）系统（TRX、TRX还原酶和NADPH）是一种普遍存在的硫醇氧化还原酶系统，可调节细胞的还原/氧化（氧化还原）状态。细胞氧化还原状态的损害会改变多种细胞途径，这可能有助于包括高血压、动脉粥样硬化和心力衰竭在内的心血管疾病的发病机制。在本手稿中，我们综述了TRX通过抗氧化作用直接限制氧化应激以及通过与硫氧还蛋白相互作用蛋白（TXNIP）等关键信号分子的蛋白质-蛋白质相互作用间接发挥的重要作用。TRX及其内源性调节因子可能是未来开发与氧化应激相关疾病临床治疗方法的重要靶点。
