Department of Respiratory Sleep Center, Nanfang Hospital, Southern Medical University, North Guangzhou Avenue 1838, Baiyun district, Guangzhou City 510515, China.
Pulm Pharmacol Ther. 2012 Apr;25(2):154-62. doi: 10.1016/j.pupt.2012.01.002. Epub 2012 Jan 25.
Thioredoxin system is a ubiquitous thiol oxidoreductase system that regulates cellular reduction/oxidation (redox) status. It includes thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH. Trx plays an essential role in cell function by limiting oxidative stress directly via antioxidant effects and indirectly by proteins interaction with key signal transduction molecules. A variety of signaling molecules have been implicated in the cytoprotection conferred by Trx, such as autophagic proteins, p38 mitogen-activated protein kinase, nuclear factor-κB, phosphatidylinositol 3-kinase. Recent studies indicated that Trx may contribute to the pathogenesis of COPD, asthma and lung injury. Enhanced Trx expression or application of recombinant Trx afforded protection in preclinical models of pulmonary tissue injury, which suggested Trx may be used in future therapeutic applications. The focus of this review is on the significance of Trx in various pulmonary diseases, which as a potential therapeutic strategy to protect against oxidative stress and inflammation.
硫氧还蛋白系统是一种普遍存在的巯基氧化还原酶系统，可调节细胞的还原/氧化（氧化还原）状态。它包括硫氧还蛋白（Trx）、硫氧还蛋白还原酶（TrxR）和 NADPH。Trx 通过直接的抗氧化作用和间接的与关键信号转导分子的蛋白质相互作用，在细胞功能中发挥着重要作用。多种信号分子已被牵连在 Trx 赋予的细胞保护作用中，如自噬蛋白、p38 丝裂原活化蛋白激酶、核因子-κB、磷脂酰肌醇 3-激酶。最近的研究表明，Trx 可能参与 COPD、哮喘和肺损伤的发病机制。在肺组织损伤的临床前模型中，增强 Trx 的表达或应用重组 Trx 提供了保护，这表明 Trx 可能用于未来的治疗应用。本综述的重点是 Trx 在各种肺部疾病中的意义，作为一种对抗氧化应激和炎症的潜在治疗策略。
