Wille-Jørgensen P, Hauch O, Dimo B, Christensen S W, Jensen R, Hansen B
Department of Surgical Gastroenterology, Bispebjerg Hospital, Copenhagen, Denmark.
Surg Gynecol Obstet. 1991 Jan;172(1):44-8.
Two hundred and forty-five patients who underwent acute extensive abdominal operations were randomized into three regimens to achieve optimal prophylaxis of postoperative thromboembolic complications. All of the patients were screened by the 125I-fibrinogen uptake test for seven days and if the phlebographic findings were positive. Of 81 patients receiving low dose heparin, 12 had thromboembolism. Of 79 receiving a combination of low dose heparin and graded compression stockings, two had thromboembolism, and of 85 receiving a combination of dextran and graded compression stockings, 13 had this complication. This difference is significant in favor of the second treatment (p = 0.013). It is concluded that the combination of low dose heparin and graded compression stockings is an effective way to prevent thromboembolism after acute abdominal operations.
245例行急性广泛性腹部手术的患者被随机分为三组，以实现对术后血栓栓塞并发症的最佳预防。所有患者均接受为期7天的125I-纤维蛋白原摄取试验筛查，若静脉造影结果为阳性。在81例接受低剂量肝素治疗的患者中，12例发生血栓栓塞。在79例接受低剂量肝素与分级加压弹力袜联合治疗的患者中，2例发生血栓栓塞，而在85例接受右旋糖酐与分级加压弹力袜联合治疗的患者中，13例发生该并发症。这种差异对第二种治疗方法有利，具有显著性（p = 0.013）。结论是，低剂量肝素与分级加压弹力袜联合使用是预防急性腹部手术后血栓栓塞的有效方法。
