Sato S, Kato S, Takahashi H, Takahashi K, Yasui S
First Department of Internal Medicine, Yamagata University School of Medicine.
Tohoku J Exp Med. 1990 Jun;161(2):73-83. doi: 10.1620/tjem.161.73.
We tested the hypothesis that during alveolar hypoxia the vasodilator response to acetylcholine (ACh) is impaired in lungs injured by intratracheal bleomycin. Isolated rat lungs were ventilated with normoxic (21% O2) or hypoxic (2% O2) gas and perfused with homologous blood. The effect of ACh on pulmonary vascular resistance was estimated during ongoing hypoxic pulmonary vasoconstriction (HPVC) after the temporal pattern of HPVC was established. The magnitude of the decrease in pulmonary vascular resistance was significantly smaller in the bleomycin-treated group (group B, n = 7) than in the saline-treated group (group S, n = 7) (p less than 0.05). The magnitude of HPVC itself did not differ between groups. The pulmonary vascular reactivities to angiotensin II and KCl were similar in the two groups (group S, n = 4, group B, n = 5). At any given transpulmonary pressure the lung volumes of group B (n = 5) were significantly smaller than those of group S (n = 4) (p less than 0.01). We conclude that vascular dilation in response to ACh during ongoing HPVC was impaired in bleomycin-injured rat lungs.
在肺泡缺氧期间，气管内注射博来霉素损伤的肺脏对乙酰胆碱（ACh）的血管舒张反应受损。将离体大鼠肺用常氧（21% O₂）或低氧（2% O₂）气体进行通气，并用同源血液进行灌注。在建立低氧性肺血管收缩（HPVC）的时间模式后，在持续的HPVC过程中评估ACh对肺血管阻力的影响。博来霉素治疗组（B组，n = 7）肺血管阻力降低的幅度明显小于生理盐水治疗组（S组，n = 7）（p < 0.05）。两组之间HPVC本身的幅度没有差异。两组对血管紧张素II和氯化钾的肺血管反应性相似（S组，n = 4；B组，n = 5）。在任何给定的跨肺压下，B组（n = 5）的肺容积明显小于S组（n = 4）（p < 0.01）。我们得出结论，在持续的HPVC期间，博来霉素损伤的大鼠肺脏对ACh的血管舒张反应受损。
