Sato S, Kato S, Arisaka Y, Takahashi H, Takahashi K, Tomoike H
First Department of Internal Medicine, Yamagata University School of Medicine.
Tohoku J Exp Med. 1993 Mar;169(3):233-44. doi: 10.1620/tjem.169.233.
Pulmonary hemodynamics of bleomycin-induced interstitial fibrosis model (group-BLM, n = 10) and saline-treated control (group-C, n = 12) were studied in awake rats. Four weeks before hemodynamic study, bleomycin sulfate and normal saline was intratracheally instilled to the group-BLM and the group-C, respectively. Pulmonary artery and abdominal aortic catheters were indwelled two days before the hemodynamic study. In room air, mean pulmonary artery pressure (Ppa) was significantly higher and systemic artery pressure was significantly lower in group-BLM than in group-C; Ppa = 21 +/- 1 cmH2O (mean +/- S.E.) for group-C and 38 +/- 4 cmH2O for group-BLM. Cardiac output did not differ among the groups. Mean pulmonary vascular resistance (PVR) of group-BLM was double that of group-C. Right ventricle was hypertrophic in group-BLM. When exposed to 10% O2, PVR of group-C significantly rose, whereas PVR of group-BLM showed very little increase, showing attenuation of the hypoxic pulmonary vasoconstriction (HPV). Magnitude of the HPV was inversely related to Ppa during air breathing. We conclude that notable pulmonary hypertension and right ventricular hypertrophy occur, and HPV is blunted four weeks after bleomycin instillation, at the most severe period of this lung fibrosis model. We speculate that the high intravascular pressure partly contributed to the blunted HPV in bleomycin-treated group.
在清醒大鼠中研究了博来霉素诱导的间质性肺纤维化模型（BLM组，n = 10）和生理盐水处理的对照组（C组，n = 12）的肺血流动力学。在进行血流动力学研究前四周，分别向BLM组和C组气管内滴注硫酸博来霉素和生理盐水。在血流动力学研究前两天留置肺动脉和腹主动脉导管。在空气中，BLM组的平均肺动脉压（Ppa）显著高于C组，而全身动脉压显著低于C组；C组的Ppa = 21±1 cmH₂O（平均值±标准误），BLM组为38±4 cmH₂O。各组的心输出量无差异。BLM组的平均肺血管阻力（PVR）是C组的两倍。BLM组右心室肥厚。当暴露于10% O₂时，C组的PVR显著升高，而BLM组的PVR几乎没有增加，显示出低氧性肺血管收缩（HPV）减弱。在呼吸空气时，HPV的程度与Ppa呈负相关。我们得出结论，在博来霉素滴注四周后，即在该肺纤维化模型的最严重阶段，出现了显著的肺动脉高压和右心室肥厚，且HPV减弱。我们推测，高血管内压部分导致了博来霉素处理组中HPV的减弱。
