[Estimation and prediction of functional changes in organisms in space flight].

The article is devoted to theoretical and applied problems of estimation of the organism functional state and a level of health. Transitive states between health and illness, between norm and a pathology, so-called prenosological states are considered. The level of health is determined by adaptable opportunities of an organism, a degree of regulatory systems tension and their functional reserve. As the basic methodical approach to an estimation of a degree of regulatory systems tension the method of heart variability analysis is described. The applied aspect of a considered problem is submitted by results of the researches which have been carried out in conditions of space flight. Changes of organism functional state at different stages of adaptation to conditions of long weightlessness are described. The mathematical model of functional states is submitted. Four types of the vegetative regulation, differing on the adaptive reactions in conditions of space flight are allocated. Results of researches of crew members of the International space station are submitted.