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Isozyme pattern of fructose diphosphate aldolase during hepatocarcinogenesis induced by 2-acetylaminofluorene in rat liver.

作者信息

Silber D, Checinska E, Rabczynski J, Kochman M

出版信息

Int J Cancer. 1975 Oct 15;16(4):682-93. doi: 10.1002/ijc.2910160418.

DOI:10.1002/ijc.2910160418
PMID:170226
Abstract

The biosynthesis of aldolase A and B subunits has been studied in rat liver during the administration of carcinogen AAF4. Transition from a predominance of aldolase B to A was observed during carcinogenesis in rat liver. Changes in isozymic pattern and FDP to F-1-P cleavage activity ratio were observed before histological alterations typical of hepatoma could be detected. Our data support the hypothesis of dedifferentiation during hepatocarcinogenesis which in an early stage results in switching on of the gene for aldolase A with simultaneous continuation of biosynthesis of aldolase B within single cells.

摘要

相似文献

1
Isozyme pattern of fructose diphosphate aldolase during hepatocarcinogenesis induced by 2-acetylaminofluorene in rat liver.
Int J Cancer. 1975 Oct 15;16(4):682-93. doi: 10.1002/ijc.2910160418.
2
Irreversible fixation of increased level of muscle type aldolase activity appearing in rat liver in the early stage of hepatocarcinogenesis.肝癌发生早期大鼠肝脏中出现的肌肉型醛缩酶活性水平升高的不可逆固定。
Cancer Res. 1970 Mar;30(3):743-52.
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Expression of aldolase A messenger RNAs in human adult and foetal tissues and in hepatoma.醛缩酶A信使核糖核酸在人类成人及胎儿组织以及肝癌中的表达。
Biochem Biophys Res Commun. 1986 Feb 13;134(3):1093-100. doi: 10.1016/0006-291x(86)90363-3.
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[Experimental study on aldolase isozyme during the development of hepatoma in the rat (author's transl)].大鼠肝癌发生过程中醛缩酶同工酶的实验研究（作者译）
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Synthesis in vitro of aldolase A by polysomes or mRNA of rat ascites hepatoma AH 7974 cells.
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Aldolase isoenzymes in liver cirrhosis and primary liver cell cancer.肝硬化和原发性肝细胞癌中的醛缩酶同工酶
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[Biochemical and immunohistochemical studies on alteration of aldolase isozymes in rat liver in the process of hepatocarcinogenesis by administration of a diet containing 3'-methyl-4-dimethylaminoazobenzene].[关于给予含3'-甲基-4-二甲基氨基偶氮苯饮食诱导大鼠肝癌发生过程中肝脏醛缩酶同工酶变化的生化及免疫组化研究]
Hokkaido Igaku Zasshi. 1989 Jul;64(4):440-9.
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Enzymes of carbohydrate metabolism in rat hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene.3'-甲基-4-二甲基氨基偶氮苯诱导的大鼠肝癌中碳水化合物代谢酶
S Afr J Med Sci. 1972 Dec;37(3):95-9.
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[Study on epoxide hydrolase in rat hyperplastic nodule and hepatoma during chemical hepatocarcinogenesis induced by 2-acetylaminofluorene (author's transl)].2-乙酰氨基芴诱导化学性肝癌发生过程中大鼠增生性结节和肝癌中环氧水解酶的研究（作者译）
Nihon Shokakibyo Gakkai Zasshi. 1982 Feb;79(2):199-204.
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Purification of aldolase C from rat brain and hepatoma.从大鼠脑和肝癌组织中纯化醛缩酶C
Eur J Biochem. 1977 Jul 1;77(1):37-43. doi: 10.1111/j.1432-1033.1977.tb11638.x.

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Aldolase activities of the small intestinal mucosa in malabsorption states and hereditary fructose intolerance.吸收不良状态和遗传性果糖不耐受时小肠黏膜的醛缩酶活性
Eur J Pediatr. 1981 Sep;137(1):5-10. doi: 10.1007/BF00441161.