人良性前列腺增生中的雌莫司汀结合蛋白

Estramustine binding protein in human benign prostatic hypertrophy.

作者信息

Shiina H, Mizutani M, Ishibe T

机构信息

Department of Urology, Shimane Medical University, Izumo-shi/Japan.

出版信息

Andrologia. 1990 Jul-Aug;22(4):309-12. doi: 10.1111/j.1439-0272.1990.tb01990.x.

DOI:10.1111/j.1439-0272.1990.tb01990.x

PMID:1702270

Abstract

Using a highly sensitive radioimmunoassay (RIA) of estramustine binding protein (EMBP) with the antibody raised against rat-EMBP, the concentration of EMBP in human benign prostatic hypertrophy (BPH) tissue was evaluated. Using mechanical separation procedure, EMBP was found significantly higher in the epithelium (10.7 ng/mg protein) than in the stroma (2.9 ng/mg protein). When human BPH was classified into glandular, fibromuscular and mixed type, the concentration of EMBP was the highest in glandular type (15.7 ng/mg protein) and the lowest in fibromuscular type (10.8 ng/mg protein).

摘要

利用针对大鼠雌莫司汀结合蛋白（EMBP）产生的抗体，通过高灵敏度放射免疫分析法（RIA）对人良性前列腺增生（BPH）组织中的EMBP浓度进行评估。采用机械分离方法，发现上皮组织中的EMBP（10.7纳克/毫克蛋白质）显著高于基质组织（2.9纳克/毫克蛋白质）。当将人BPH分为腺型、纤维肌型和混合型时，EMBP浓度在腺型中最高（15.7纳克/毫克蛋白质），在纤维肌型中最低（10.8纳克/毫克蛋白质）。