Shiina H, Sumi H, Ishibe T, Usui T
Department of Urology, Shimane Medical University, Izumo, Japan.
Urol Int. 1994;52(4):213-6. doi: 10.1159/000282611.
For the purpose of elucidating the clinical significance of estramustine binding protein (EMBP), EMBP concentration in human prostatic carcinoma (PC) tissue was measured by radioimmunoassay (RIA) using an antibody raised against rat EMBP and was compared with dihydrotestosterone (DHT) level and histological differentiation in the same tissue. The mean concentrations of EMBP in 20 untreated and 6 hormonally refractory PC were 112.6 +/- 120.7 and 218.0 +/- 102.3 ng/g tissue, respectively. In the 20 untreated PC, the EMBP concentration was not significantly different between the high and low tissue DHT groups. On the other hand, the EMBP concentration was significantly higher in moderately and poorly differentiated PCs as compared with well-differentiated PC, whereas the DHT level was highest in well-differentiated and lowest in poorly differentiated PC. Furthermore, in the 6 hormonally refractory PC, the EMBP concentration was higher in spite of a lower tissue DHT level in comparison with untreated PC. These results suggest that the EMBP concentration does not reflect androgen status in PC tissue but might reflect the malignant potential of the tumor.
为阐明雌莫司汀结合蛋白（EMBP）的临床意义，采用抗大鼠EMBP抗体，通过放射免疫分析法（RIA）测定人前列腺癌（PC）组织中的EMBP浓度，并与同一组织中的双氢睾酮（DHT）水平和组织学分化情况进行比较。20例未经治疗的PC和6例激素难治性PC中EMBP的平均浓度分别为112.6±120.7和218.0±102.3 ng/g组织。在20例未经治疗的PC中，高组织DHT组和低组织DHT组的EMBP浓度无显著差异。另一方面，中分化和低分化PC的EMBP浓度显著高于高分化PC，而DHT水平在高分化PC中最高，在低分化PC中最低。此外，在6例激素难治性PC中，尽管组织DHT水平低于未经治疗的PC，但其EMBP浓度更高。这些结果表明，EMBP浓度不能反映PC组织中的雄激素状态，但可能反映肿瘤的恶性潜能。
