Reinblatt Shauna L, Morin Lucie, Meltzer Sara J
Department of Obstetrics and Gynecology, Royal Victoria Hospital, Montreal QC.
Department of Obstetrics and Gynecology, Royal Victoria Hospital, Montreal QC; Department of Medicine, Division of Endocrinology, Royal Victoria Hospital, Montreal QC.
J Obstet Gynaecol Can. 2006 Aug;28(8):690-694. doi: 10.1016/S1701-2163(16)32230-7.
To compare the ability of the fasting plasma glucose (FPG) level with the ability of the 2-hour oral glucose tolerance test (OGTT) to identify women with any form of glucose intolerance within the first six postpartum months.
In a retrospective, observational analysis, the predictive ability of the FPG level was compared with that of the 2-hour OGTT in 275 women followed for gestational diabetes who returned for postpartum testing.
With use of the FPG level alone, 4.4% of the women were found to have an FPG 7.0 mmol/L, identifying diabetes mellitus (DM); 2.5% had an FPG in the range 6.1-6.9 mmol/L, identifying impaired fasting glucose (IFG); and 93% had an FPG 6.0 mmol/L, i.e., within the normal range. Using the 2-hour 75g OGTT, 5% of women were found to have either an FPG 7.0 mmol/L or a 2-hour plasma glucose (PG) 11.1 mmol/L, identifying DM; 2.5% had an FPG of 6.1-6.9 mmol/L, identifying IFG; and 32% had a 2-hour PG of 7.8-11.0 mmol/L, identifying impaired glucose tolerance (IGT). Of the women with any glucose abnormality postpartum, an FPG level alone detected 15.8%, the post-glucose load level detected 97.5%, and an OGTT detected 100% of the women. An FPG level alone in 39% of cases failed to detect either IGT or DM and in 54% of cases, type 2 DM.
In view of the potential for early, effective prevention of DM, the optimal method for detecting glucose abnormalities in women within six months post partum is a 2-hour OGTT.
比较空腹血糖（FPG）水平与2小时口服葡萄糖耐量试验（OGTT）识别产后头6个月内患有任何形式糖耐量异常女性的能力。
在一项回顾性观察分析中，比较了275例患有妊娠期糖尿病且产后返回进行检测的女性中FPG水平与2小时OGTT的预测能力。
仅使用FPG水平时，发现4.4%的女性FPG≥7.0 mmol/L，诊断为糖尿病（DM）；2.5%的女性FPG在6.1 - 6.9 mmol/L范围内，诊断为空腹血糖受损（IFG）；93%的女性FPG＜6.0 mmol/L，即处于正常范围内。使用2小时75g OGTT时，发现5%的女性FPG≥7.0 mmol/L或2小时血浆葡萄糖（PG）≥11.1 mmol/L，诊断为DM；2.5%的女性FPG为6.1 - 6.9 mmol/L，诊断为IFG；32%的女性2小时PG为7.8 - 11.0 mmol/L，诊断为糖耐量受损（IGT）。在产后有任何血糖异常的女性中，仅FPG水平检测出15.8%，葡萄糖负荷后水平检测出97.5%，OGTT检测出100%。仅FPG水平在39%的病例中未能检测出IGT或DM，在54%的病例中未能检测出2型DM。
鉴于早期有效预防DM的可能性，产后6个月内检测女性血糖异常的最佳方法是2小时OGTT。
