Boukh-Viner Tatiana, Titorenko Vladimir I
Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-9, Montreal, Quebec, Canada H4B 1R6.
Biochim Biophys Acta. 2006 Dec;1763(12):1688-96. doi: 10.1016/j.bbamcr.2006.08.016. Epub 2006 Aug 23.
Biological membranes have unique and highly diverse compositions of their lipid constituents. At present, we have only partial understanding of how membrane lipids and lipid domains regulate the structural integrity and functionality of cellular organelles, maintain the unique molecular composition of each organellar membrane by orchestrating the intracellular trafficking of membrane-bound proteins and lipids, and control the steady-state levels of numerous signaling molecules generated in biological membranes. Similar to other organellar membranes, a single lipid bilayer enclosing the peroxisome, an organelle known for its essential role in lipid metabolism, has a unique lipid composition and organizes some of its lipid and protein components into distinctive assemblies. This review highlights recent advances in our knowledge of how lipids and lipid domains of the peroxisomal membrane regulate the processes of peroxisome assembly and maintenance in the yeast Yarrowia lipolytica. We critically evaluate the molecular mechanisms through which lipid constituents of the peroxisomal membrane control these multistep processes and outline directions for future research in this field.
生物膜的脂质成分具有独特且高度多样化的组成。目前，我们对膜脂和脂域如何调节细胞器的结构完整性和功能、通过协调膜结合蛋白和脂质的细胞内运输来维持每个细胞器膜的独特分子组成，以及控制生物膜中产生的众多信号分子的稳态水平，仅有部分了解。与其他细胞器膜类似，包裹过氧化物酶体的单层脂质双分子层具有独特的脂质组成，并将其一些脂质和蛋白质成分组织成独特的组装体。过氧化物酶体因其在脂质代谢中的重要作用而闻名。本综述重点介绍了我们对解脂耶氏酵母过氧化物酶体膜的脂质和脂域如何调节过氧化物酶体组装和维持过程的最新认识。我们批判性地评估了过氧化物酶体膜的脂质成分控制这些多步骤过程的分子机制，并概述了该领域未来的研究方向。
