McCrink Louise, Allen Richard P, Wolowacz Sorrel, Sherrill Beth, Connolly Mark, Kirsch Jeff
RTI Health Solutions, Williams House, Manchester Science Park, Manchester, Lancashire M15 6SE, UK.
Sleep Med. 2007 Jan;8(1):73-83. doi: 10.1016/j.sleep.2006.03.014. Epub 2006 Oct 4.
To explore aspects of restless legs syndrome (RLS) associated with detrimental impact on health-related quality of life (HRQoL).
The RLS epidemiology, symptoms, and treatment (REST) survey included SF-36 data on adults with RLS symptoms in the USA and five European countries. Linear regression models on each SF-36 dimension score explored factors influencing HRQoL in this population.
Of 16,202 people surveyed, 7% screened positively for RLS. Severity of RLS symptoms was strongly associated with impaired physical and mental HRQoL in both the cohorts from the USA and Europe. Distress and symptom frequency also had predictive capability. In addition, significantly diminished HRQoL was associated with the use of prescription medication for RLS symptoms. Age, number of comorbidities, and number of physician visits were statistically associated with lower HRQoL in respondents with RLS.
Diminished HRQoL was partly accounted for by a number of RLS-related factors, including frequency, severity, and distress from symptoms. The negative impact of prescription medications on HRQoL, in contrast to demonstrated improvements with dopamine agonists, suggests inappropriate or ineffective medications are being used in this population. Our results strongly support the need for better physician education, both to diagnose the condition and importantly provide appropriate treatment with dopamine agonists, the only class of medication, that has been shown to improve the HRQoL of patients with RLS.
探讨不宁腿综合征（RLS）对健康相关生活质量（HRQoL）产生不利影响的相关方面。
RLS流行病学、症状及治疗（REST）调查纳入了来自美国和五个欧洲国家有RLS症状成年人的SF - 36数据。对每个SF - 36维度得分建立线性回归模型，以探究影响该人群HRQoL的因素。
在16202名接受调查者中，7%的人RLS筛查呈阳性。在美国和欧洲的队列中，RLS症状的严重程度均与身心HRQoL受损密切相关。痛苦程度和症状频率也具有预测能力。此外，HRQoL显著降低与使用治疗RLS症状的处方药有关。年龄、合并症数量和看医生次数在有RLS的受访者中与较低的HRQoL存在统计学关联。
HRQoL降低部分是由一些与RLS相关的因素导致的，包括症状频率、严重程度和痛苦程度。与多巴胺激动剂已证实的改善效果相比，处方药对HRQoL产生负面影响，这表明该人群使用了不适当或无效的药物。我们的结果有力地支持了加强医生培训的必要性，以便既能诊断该病，又能重要地提供多巴胺激动剂这一唯一已被证明可改善RLS患者HRQoL的药物进行恰当治疗。
