Lin Q, Li C D, Li P
Department of Physiology, Shanghai Medical University, People's Republic of China.
Brain Res. 1990 Oct 22;530(2):317-20. doi: 10.1016/0006-8993(90)91302-w.
Intrathecal (i.t.) infusion of substance P (SP) antagonist, (D-Pro2, D-Trp7,9)-substance P (20 micrograms), lowered blood pressure profoundly without any significant change of heart rate. The hypertensive and tachycardic responses elicited by microinjection of carbachol (25 ng/site) into the bilateral rostral ventrolateral medulla (rVLM) were blocked by i.t. infusion of SP antagonist. These data provided evidence that an excitatory cardiovascular effect induced by cholinergic system in rVLM may be mediated mainly by the SP receptors in spinal cord.
鞘内注射P物质（SP）拮抗剂（D-脯氨酸2，D-色氨酸7,9）-P物质（20微克）可显著降低血压，而心率无明显变化。向双侧延髓头端腹外侧区（rVLM）微量注射卡巴胆碱（25纳克/位点）所引发的高血压和心动过速反应，可被鞘内注射SP拮抗剂所阻断。这些数据证明，rVLM中胆碱能系统诱导的兴奋性心血管效应可能主要由脊髓中的SP受体介导。
