Loewy A D, Sawyer W B
Brain Res. 1982 Aug 12;245(2):379-83. doi: 10.1016/0006-8993(82)90822-8.
Application of kainic acid to the ventral medulla in rats leads to increases in blood pressure and heart rate. These responses can be attenuated or reversed by infusion of the substance P antagonist--(D-Pro2,D-Trp7,9)-substance P into the spinal subarachnoid space. Kainic acid elicits normal pressor responses from rats that have been treated intracisternally with the serotonin neurotoxin 5,7-dihydroxytryptamine. These results suggest that the substance P-like neurons of the ventral medulla may play a role in maintaining vasomotor tone.
将海藻酸应用于大鼠延髓腹侧会导致血压和心率升高。通过向脊髓蛛网膜下腔注入P物质拮抗剂——(D-脯氨酸2，D-色氨酸7，9)-P物质，这些反应可以减弱或逆转。海藻酸能引发经脑池内注射5，7-二羟色胺（一种血清素神经毒素）处理的大鼠产生正常的升压反应。这些结果表明，延髓腹侧的P物质样神经元可能在维持血管运动张力方面发挥作用。
