肾母细胞瘤中发生的复发性肾细胞癌。

Recurrent renal cell carcinoma arising in Wilms' tumor.

作者信息

Allsbrook W C, Boswell W C, Takahashi H, Pantazis C G, Howell C G, Martinez J E, Beck J R

机构信息

Department of Pathology, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912-3605.

出版信息

Cancer. 1991 Feb 1;67(3):690-5. doi: 10.1002/1097-0142(19910201)67:3<690::aid-cncr2820670327>3.0.co;2-f.

DOI:10.1002/1097-0142(19910201)67:3<690::aid-cncr2820670327>3.0.co;2-f

PMID:1702357

Abstract

A 19-month-old black girl had a radical nephrectomy for a Wilms' tumor that contained areas of epithelium indistinguishable from renal cell carcinoma. She was treated with chemotherapy but subsequently had pulmonary metastases develop and massive abdominal recurrence. The recurrent tumor was histologically renal cell carcinoma with no identifiable Wilms' tumor elements. The child died with recurrent and metastatic tumor 13 months after nephrectomy. Pathologic, immunoperoxidase, and flow cytometric studies of this unusual case are presented.

摘要

一名19个月大的黑人女孩因患有肾母细胞瘤接受了根治性肾切除术，该肿瘤中含有一些与肾细胞癌难以区分的上皮区域。她接受了化疗，但随后出现了肺转移和腹部大量复发。复发性肿瘤在组织学上为肾细胞癌，未发现可识别的肾母细胞瘤成分。该患儿在肾切除术后13个月因肿瘤复发和转移而死亡。本文介绍了这一罕见病例的病理学、免疫过氧化物酶和流式细胞术研究结果。