Zou Xiao-Ping, Jiang Yao-Ying, Liao Yan, Dang Yi-Wu, Chen Gang, Feng Zhen-Bo, Ma Yun
Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China,
Department of Pathology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Onco Targets Ther. 2019 Jan 30;12:953-958. doi: 10.2147/OTT.S186102. eCollection 2019.
A combination of a Wilms' tumor (WT) and renal cell carcinoma (RCC) is an extremely rare pediatric renal neoplasm. Its prognosis and clinicopathological features remain unclarified. Herein, we describe a case of the coexistence of a WT and an RCC in a male child aged 5 years and 10 months. The child had symptoms of hematuria for more than 1 month. Although his irises were clear, medical imaging revealed a potential malignant tumor in the left kidney. The patient underwent resection of the left kidney. The pathological diagnosis was the coexistence of a WT and papillary RCC. Negative surgical margins were examined. One month following the resection, chemotherapy with vincristine plus dactinomycin (EE-4A regimen) was commenced. At the 69-month follow-up, there was no recurrence or metastasis. The coexistence of a WT and an RCC in the pediatric population is considered a rare pathological event. At present, there is no standard treatment for these renal neoplasms. In this study, the RCC treatment, which was the same as that applied in cases of WTs, was reasonable.
肾母细胞瘤（WT）与肾细胞癌（RCC）并存是一种极其罕见的小儿肾脏肿瘤。其预后及临床病理特征仍不明确。在此，我们描述一例5岁10个月男童肾母细胞瘤与肾细胞癌并存的病例。该患儿有1个多月的血尿症状。尽管其虹膜清晰，但医学影像显示左肾有一个潜在的恶性肿瘤。患者接受了左肾切除术。病理诊断为肾母细胞瘤与乳头状肾细胞癌并存。检查手术切缘阴性。切除术后1个月，开始采用长春新碱加放线菌素D化疗（EE - 4A方案）。在69个月的随访中，未出现复发或转移。小儿人群中肾母细胞瘤与肾细胞癌并存被认为是一种罕见的病理情况。目前，对于这些肾脏肿瘤尚无标准治疗方法。在本研究中，对肾细胞癌的治疗与肾母细胞瘤病例相同，是合理的。
