Marocchio Luciana S, Pereira Michele C, Soares Cléverson T, Oliveira Denise T
Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Brazil.
J Oral Sci. 2006 Sep;48(3):157-60. doi: 10.2334/josnusd.48.157.
An unusual case of isolated plexiform neurofibroma arising in the oral cavity without other clinical manifestations or family history of neuro-fibromatosis-1 (NF-1) is described. The tumor was histopathologically analyzed and an immunohistochemical panel comprising S-100 protein, epithelial membrane antigen (EMA), collagen IV, and CD34 was performed. Typical features of plexiform neurofibroma characterized by enlarged nerve fascicles composed of elongated nuclei and scant cytoplasm cells were identified. Subjacent to the oral epithelium, tactile-like bodies were also detected. On the basis of this report, we would like to emphasize that plexiform neurofibroma can occur in the oral cavity as a benign isolated tumor in patients without other stigmata of NF-1.
本文描述了一例罕见的孤立性丛状神经纤维瘤，该肿瘤发生于口腔，无神经纤维瘤病1型（NF-1）的其他临床表现或家族史。对肿瘤进行了组织病理学分析，并进行了包括S-100蛋白、上皮膜抗原（EMA）、IV型胶原和CD34在内的免疫组织化学检测。发现了丛状神经纤维瘤的典型特征，即由拉长的细胞核和少量细胞质细胞组成的神经束增粗。在口腔上皮下方，还检测到触觉样小体。基于本报告，我们想强调，丛状神经纤维瘤可作为良性孤立性肿瘤发生于无NF-1其他体征的患者口腔中。
