Meng G, Smith P D
Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham School of Medicine and the VA Medical Center, University of Alabama Station, Birmingham, AL 35294, USA.
Curr Opin Gastroenterol. 1999 Jan;15(1):85-9. doi: 10.1097/00001574-199901000-00015.
Gastrointestinal infections are a frequent and important complication of immunodeficiency diseases and immunosuppressive therapy. Such infections may be severe, prolonged, or even fatal, whereas the same infections are typically mild and transient in immunocompetent persons. In this regard, the strong association between HIV-induced immunosuppression and the increased prevalence of severe enteric infections is strong evidence of the link between immune function and defense against enteric pathogens. Because gastrointestinal infections in immunocompromised persons are frequently severe and life-threatening, a vigorous approach to the diagnostic evaluation and therapeutic management is advocated by many clinical investigators. In this review, we summarize the important new developments, particularly during the past year, regarding gastrointestinal infections in immunocompromised persons.
胃肠道感染是免疫缺陷疾病和免疫抑制治疗常见且重要的并发症。此类感染可能严重、持续时间长甚至致命，而同样的感染在免疫功能正常者中通常症状轻微且短暂。在这方面，HIV 诱导的免疫抑制与严重肠道感染患病率增加之间的紧密关联，有力证明了免疫功能与抵御肠道病原体之间的联系。由于免疫功能低下者的胃肠道感染常常严重且危及生命，许多临床研究人员主张采取积极的诊断评估和治疗管理方法。在本综述中，我们总结了免疫功能低下者胃肠道感染方面的重要新进展，特别是过去一年的进展。
