Kagei K, Suzuki K, Shirato H, Nambu T, Yoshikawa H, Irie G
Dept. of Radiology, Obihiro Kosei Hospital.
Gan No Rinsho. 1990 Dec;36(15):2553-8.
From April, 1989 through January, 1990, a randomized trial was conducted to investigate the efficacy of single fraction radiation treatment (8, 10, 12, 15Gy) compared to a multifraction dose schedule (5Gy x 4, 5Gy x 5, 5Gy x 6) as a therapy for a bone metastasis. Both subjective and objective pain scores were used to measure the therapeutic results. A total of 31 patients participated in the trial and, for analysis, 27 of these patients were follow-up for more than 8 weeks after the start of the radiation therapy. The following statistics resulted. Of the single fraction series, symptomatic pain relief was obtained in 86% of the patients (12/14 treatment areas), and of the multifraction series, 92% (12/13). Further, a complete response was achieved in 57% (8/14) of the single fraction patients and 31% (4/13) of the multifraction patients, respectively. Between the two treatment regimens, no difference was found in the incidence of pain relief, speed of onset, or acute morbidity. Finally, no severe morbidity was seen in either arm.
从1989年4月至1990年1月，开展了一项随机试验，以研究单次分割放射治疗（8、10、12、15Gy）与多分割剂量方案（5Gy×4、5Gy×5、5Gy×6）作为骨转移瘤治疗方法的疗效。主观和客观疼痛评分均用于衡量治疗结果。共有31名患者参与该试验，为进行分析，其中27名患者在放射治疗开始后随访超过8周。得出以下统计结果。在单次分割组中，86%（12/14个治疗区域）的患者获得了症状性疼痛缓解，在多分割组中，这一比例为92%（12/13）。此外，单次分割组患者和多分割组患者分别有57%（8/14）和31%（4/13）实现了完全缓解。在两种治疗方案之间，疼痛缓解发生率、起效速度或急性发病率均未发现差异。最后，两组均未出现严重并发症。
