Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Division of Radiation Oncology, University of Ottawa, Ottawa, Ontario, Canada.
J Bone Oncol. 2015 Jan 23;4(1):13-7. doi: 10.1016/j.jbo.2014.12.001. eCollection 2015 Mar.
The most recent systematic review of randomized trials in patients with bone metastases has shown equal efficacy of single fraction (SF) and multiple fraction (MF) palliative radiation therapy in pain relief. It is important to determine the patient population to which the evidence applies. This study aims to examine the eligibility criteria of the studies included in the systematic review to define characteristics of "uncomplicated" bone metastases. Inclusion and exclusion criteria of 21 studies included in the systematic review were compared. Common eligibility criteria were documented in hopes of defining the specific features of a common patient population representative of those in the studies. More than half of the studies included patients with cytological or histological evidence of malignancy. Patients with impending and/or existing pathological fracture, spinal cord compression or cauda equina compression were excluded in most studies. Most studies also excluded patients receiving retreatment to the same site. "Uncomplicated" bone metastases can be defined as: presence of painful bone metastases unassociated with impending or existing pathologic fracture or existing spinal cord or cauda equina compression. Therefore, MF and SF have equal efficacy in patients with such bone metastases.
最近对患有骨转移的患者进行的随机试验的系统评价表明，单次分割（SF）和多次分割（MF）姑息性放射治疗在缓解疼痛方面具有同等疗效。重要的是要确定证据适用的患者人群。本研究旨在检查系统评价中纳入的研究的纳入标准，以确定“无并发症”骨转移的特征。比较了系统评价中纳入的 21 项研究的纳入和排除标准。记录了常见的纳入标准，希望能定义出具有代表性的常见患者人群的具体特征。超过一半的研究纳入了有细胞学或组织学恶性证据的患者。大多数研究排除了即将发生和/或存在病理性骨折、脊髓压迫或马尾神经压迫的患者。大多数研究还排除了对同一部位进行再治疗的患者。“无并发症”骨转移可定义为：存在疼痛性骨转移，不伴有即将发生或存在的病理性骨折或现有脊髓或马尾神经压迫。因此，MF 和 SF 在具有此类骨转移的患者中具有同等疗效。
