Sun Xiao-Feng, Zhang Hong
Department of Oncology, Institute of Biomedicine and Surgery, University of Linköping, SE-581 85 Linköping, Sweden.
Mol Cancer. 2006 Oct 6;5:43. doi: 10.1186/1476-4598-5-43.
Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, stromal variables within or around tumours, including blood and lymph vessels, stromal cells and various proteins, have also important impacts on tumour development and progression. It has been shown that disruption of stromal-epithelial interactions influences cellular proliferation, differentiation, death, motility, genomic integrity, angiogenesis, and other phenotypes in various tissues. Moreover, stromal variables are also critical to therapy in cancer patients. In this review, we mainly focus on the clinicopathological significance of stromal variables including angiogenesis, lymphangiogenesis, inflammatory infiltration, matrix metalloproteinase (MMP), and the particularly interesting new cysteine-histidine rich protein (PINCH) in colorectal cancer (CRC).
癌症研究主要集中在癌细胞自身的基因和蛋白质改变上，这些改变导致癌基因功能获得或肿瘤抑制基因功能丧失。然而，肿瘤内部或周围的基质变量，包括血管、淋巴管、基质细胞和各种蛋白质，对肿瘤的发生发展也有重要影响。研究表明，基质 - 上皮相互作用的破坏会影响各种组织中的细胞增殖、分化、死亡、运动、基因组完整性、血管生成及其他表型。此外，基质变量对癌症患者的治疗也至关重要。在本综述中，我们主要关注基质变量在结直肠癌（CRC）中的临床病理意义，这些变量包括血管生成、淋巴管生成、炎症浸润、基质金属蛋白酶（MMP）以及特别有趣的富含半胱氨酸 - 组氨酸的新蛋白（PINCH）。
