University of Antwerp, Belgium.
Eur J Cancer Prev. 2010 May;19(3):204-15. doi: 10.1097/CEJ.0b013e32833720de.
The carcinogenesis of cervical carcinoma implies an intricate interplay of neoplastic, human papillomavirus infected epithelial cells and stromal tissue, in which different factors have distinct but interacting influence. Persistent infection with an oncogenic human papillomavirus type may lead to epithelial dysplasia with progressive severity. To access the adjacent stromal tissue, tumour cells have to breach the basement membrane. The stroma partly controls tumour growth, invasion and angiogenesis. Last but not least there is considerable influence of the immune response. In this review we describe the importance of various stromal factors in carcinogenesis of cervical cancer.
宫颈癌的癌变涉及肿瘤性、人乳头瘤病毒感染的上皮细胞和基质组织的复杂相互作用，其中不同的因素具有不同但相互作用的影响。持续性感染致癌性人乳头瘤病毒可能导致上皮异型增生，且其严重程度逐渐加重。为了侵犯相邻的基质组织，肿瘤细胞必须突破基底膜。基质部分控制肿瘤的生长、浸润和血管生成。最后但并非最不重要的是，免疫反应也有相当大的影响。在这篇综述中，我们描述了各种基质因素在宫颈癌发生中的重要性。
