Nakajima T, Ichikawa S, Uchida S, Komada T
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Clin Ther. 1990 Sep-Oct;12(5):385-92.
PSK, extracted from mycelia of a strain of Coriolus versicolor, was administered to groups of 20 male Wistar rats before and during treatment with 3'-methyl-4-dimethylaminoazobenzene (3-MDAB). After 24 weeks, the survival rates were significantly higher in the groups given PSK before or with the 3-MDAB than in groups not given PSK or given PSK after 12 weeks of 3-MDAB treatment. Blood alpha-fetoprotein levels, determined every four weeks, increased in all groups after 3-MDAB treatment, but were significantly lower in the groups given PSK before or with the 3-MDAB than in the other groups. The results indicate that PSK had a suppressive effect on 3-MDAB-induced hepatocarcinogenesis.
从一株云芝的菌丝体中提取的PSK，在给予20只雄性Wistar大鼠3'-甲基-4-二甲基氨基偶氮苯（3-MDAB）治疗之前及治疗期间给药。24周后，在3-MDAB治疗前或治疗期间给予PSK的组的存活率显著高于未给予PSK或在3-MDAB治疗12周后给予PSK的组。每四周测定一次血甲胎蛋白水平，3-MDAB治疗后所有组的血甲胎蛋白水平均升高，但在3-MDAB治疗前或治疗期间给予PSK的组显著低于其他组。结果表明，PSK对3-MDAB诱导的肝癌发生有抑制作用。
