Taga H
Gan. 1983 Apr;74(2):248-57.
Immunization of rats with a purified mouse alpha-fetoprotein (AFP) suspended in Freund's complete adjuvant resulted in the production of antibodies that could precipitate both mouse and rat AFPs. A group of rats was immunized first and then fed a diet containing 0.06% 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) for 10 weeks. In these rats the elevation of serum AFP as well as the development of hepatoma were markedly inhibited. Another group of rats was immunized after feeding the diet containing 3'-Me-DAB for 10 weeks. The development of hepatoma and production of serum AFP were also suppressed. In both groups the life span of the rats was prolonged by the immunization.
用悬浮于弗氏完全佐剂中的纯化小鼠甲胎蛋白（AFP）对大鼠进行免疫，可产生能沉淀小鼠和大鼠AFP的抗体。一组大鼠先进行免疫，然后喂食含0.06% 3'-甲基-4-二甲基氨基偶氮苯（3'-Me-DAB）的饲料10周。在这些大鼠中，血清AFP的升高以及肝癌的发生均受到明显抑制。另一组大鼠在喂食含3'-Me-DAB的饲料10周后进行免疫。肝癌的发生和血清AFP的产生也受到抑制。在两组中，免疫均延长了大鼠的寿命。
