Magnay Julia L, Ismail Khaled M K, Chapman Gail, Cioni Leanne, Jones Peter W, O'Brien Shaughn
Institute of Science and Technology in Medicine, Keele University, Staffordshire, UK.
Am J Obstet Gynecol. 2006 Nov;195(5):1254-9. doi: 10.1016/j.ajog.2006.06.087. Epub 2006 Oct 5.
The purpose of this study was to investigate whether common polymorphisms of key genes that control the serotonin (5-hydroxytryptamine) pathway are associated with premenstrual dysphoric disorder.
The study sample comprised 53 women with clinically diagnosed premenstrual dysphoric disorder (age range, 27-46 years; mean age, 37.7 years) and 52 healthy control subjects (age range, 22-48 years; mean age, 36.2 years). Eight polymorphisms that encode the 5-hydroxytryptamine transporter (LPR, VNTR-2, and 3' UTR G/T), tryptophan hydroxylase 1 (TPH1 G-6526A, G-5806T, and A218C), and monoamine oxidase A (monoamine oxidase A promoter VNTR-1 and exon 8 Fnu 4H1) were genotyped. Genotype and allelic frequencies were analyzed by chi-square test and stepwise logistic regression analysis.
There was no significant association between any genotype and clinical category and no significant allelic distribution profiles in either the premenstrual dysphoric disorder group or the control group.
These findings do not support a major role for common 5-hydroxytryptamine transporter, TPH1, and monoamine oxidase A polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.
本研究旨在调查控制血清素（5-羟色胺）途径的关键基因的常见多态性是否与经前烦躁障碍相关。
研究样本包括53名临床诊断为经前烦躁障碍的女性（年龄范围27 - 46岁；平均年龄37.7岁）和52名健康对照者（年龄范围22 - 48岁；平均年龄36.2岁）。对编码5-羟色胺转运体（LPR、VNTR - 2和3'UTR G/T）、色氨酸羟化酶1（TPH1 G - 6526A、G - 5806T和A218C）以及单胺氧化酶A（单胺氧化酶A启动子VNTR - 1和外显子8 Fnu 4H1）的8种多态性进行基因分型。通过卡方检验和逐步逻辑回归分析对基因型和等位基因频率进行分析。
在经前烦躁障碍组或对照组中，任何基因型与临床分类之间均无显著关联，且等位基因分布特征也无显著差异。
这些发现不支持常见的5-羟色胺转运体、TPH1和单胺氧化酶A多态性在经前烦躁障碍易感性中起主要作用。
