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5-羟色胺受体1A C(-1019)G多态性与经前烦躁障碍相关。

Serotonin receptor 1A C(-1019)G polymorphism associated with premenstrual dysphoric disorder.

作者信息

Dhingra Vandana, Magnay Julia L, O'Brien P M Shaughn, Chapman Gail, Fryer Anthony A, Ismail Khaled M K

机构信息

Academic Unit of Obstetrics and Gynecology, Keele University Medical School, University Hospital of North Staffordshire, United Kingdom.

出版信息

Obstet Gynecol. 2007 Oct;110(4):788-92. doi: 10.1097/01.AOG.0000284448.73490.ac.

Abstract

OBJECTIVE

To assess whether the G allele of the serotonin receptor 1A C(-1019)G polymorphism is associated with premenstrual dysphoric disorder.

METHODS

The study sample comprised 53 women with clinically diagnosed premenstrual dysphoric disorder (age range 27-46 years, mean 37.7 years) and 51 healthy control subjects (age range 22-48 years, mean 36.2 years). The serotonin receptor 1A C(-1019)G polymorphism was genotyped and compared between the two groups.

RESULTS

In contrast to the postulated "high-risk" G/G genotype, there was a marked overrepresentation of the C/C genotype in the premenstrual dysphoric disorder group (P=.034; odds ratio 3.63, 95% confidence interval 1.22-10.78). The presence of at least one C allele was associated with a 2.5-fold increased risk of premenstrual dysphoric disorder (P=.053; odds ratio 2.46, 95% confidence interval 1.03-5.88).

CONCLUSION

Our hypothesis that the high-risk G allele is associated with the occurrence of premenstrual dysphoria was not proved in this study. However, due to the increased prevalence of the C variant, we suggest that the C(-1019) allele may contribute to the risk of premenstrual dysphoria.

LEVEL OF EVIDENCE

II.

摘要

目的

评估5-羟色胺受体1A基因C(-1019)G多态性的G等位基因是否与经前烦躁障碍相关。

方法

研究样本包括53例临床诊断为经前烦躁障碍的女性(年龄范围27 - 46岁,平均37.7岁)和51例健康对照者(年龄范围22 - 48岁,平均36.2岁)。对两组进行5-羟色胺受体1A基因C(-1019)G多态性基因分型并比较。

结果

与假定的“高风险”G/G基因型相反,经前烦躁障碍组中C/C基因型显著过多(P = 0.034;优势比3.63,95%置信区间1.22 - 10.78)。至少存在一个C等位基因与经前烦躁障碍风险增加2.5倍相关(P = 0.053;优势比2.46,95%置信区间1.03 - 无5.88)。

结论

本研究未证实我们关于高风险G等位基因与经前烦躁症发生相关的假设。然而,由于C变异体的患病率增加,我们认为C(-1019)等位基因可能与经前烦躁症风险有关。

证据水平

II级。 (注:原文“95% confidence interval 1.03 - 无5.88”这里可能有误,推测应为“95% confidence interval 1.03 - 5.88”,翻译时按推测内容翻译)

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