Cai Yan, Meng Xin-fang, Cao Yong-xiao, Lu Hua, Zhu Shao-fei, Zhou Liang-zhen
Department of Pharmacology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, 710061, PR China.
Eur J Pharmacol. 2006 Dec 3;551(1-3):156-61. doi: 10.1016/j.ejphar.2006.08.053. Epub 2006 Sep 7.
The present study aims to evaluate the adsorbing effect of montmorillonite on thyroid hormone in the entero-hepatic circulation. The concentration of thyroid hormone in the serum of hyperthyroidism model rats and in solution was measured by radioimmunoassay and ultraviolet spectrometry, respectively. The body weight, temperature, and consumption of food and water were observed in hyperthyroidism model rats. Furthermore, hypoxia tolerance, sodium-pentobarbital-induced sleep time, spontaneous activities were measured on hyperthyroidism model mice after being treated with montmorillonite. Results showed that montmorillonite adsorbed thyroxin (T(4)) and triiodothyronine (T(3)) in vitro. Montmorillonite at dosage of 1.0 g/kg and 0.3 g/kg decreased thyroid hormone levels on hyperthyroidism model rats; Montmorillonite (2.0 g/kg and 0.6 g/kg) prolonged the sleep time, improved the hypoxia tolerant capacity and reduced the spontaneous activities of the hyperthyroidism model mice. These results suggest montmorillonite has anti-hyperthyroidism effect attributed to its adsorptive effect.
本研究旨在评估蒙脱石对肠肝循环中甲状腺激素的吸附作用。分别采用放射免疫分析法和紫外光谱法测定甲亢模型大鼠血清及溶液中甲状腺激素的浓度。观察甲亢模型大鼠的体重、体温以及食物和水的消耗量。此外，对甲亢模型小鼠给予蒙脱石治疗后，测定其耐缺氧能力、戊巴比妥钠诱导的睡眠时间、自发活动。结果表明，蒙脱石在体外能吸附甲状腺素（T4）和三碘甲状腺原氨酸（T3）。剂量为1.0 g/kg和0.3 g/kg的蒙脱石可降低甲亢模型大鼠的甲状腺激素水平；蒙脱石（2.0 g/kg和0.6 g/kg）可延长甲亢模型小鼠的睡眠时间，提高其耐缺氧能力，并减少其自发活动。这些结果表明，蒙脱石因其吸附作用而具有抗甲亢作用。
