Kabadi U M
Am Fam Physician. 1982 Sep;26(3):183-8.
Appropriate dosage of levothyroxine for the treatment of hypothyroidism is assessed by determining the serum thyroxine (T4) concentration in secondary and tertiary types. In primary hypothyroidism, the optimal thyroid replacement is that which induces a normal thyroid-stimulating hormone level and a normal TSH response to administration of thyrotropin-releasing hormone. Hypothyroidism often occurs in the management of hyperthyroidism. Serial serum TSH measurements help in the early detection of hypothyroidism, whereas serum triiodothyronine (T3) aids in prompt recognition of recurrence of hyperthyroidism.
对于继发性和三发性甲状腺功能减退症，通过测定血清甲状腺素（T4）浓度来评估左甲状腺素治疗的合适剂量。在原发性甲状腺功能减退症中，最佳的甲状腺替代治疗是使促甲状腺激素水平正常化，并使促甲状腺激素释放激素给药后的促甲状腺激素反应正常化。甲状腺功能减退症常发生于甲状腺功能亢进症的治疗过程中。连续测定血清促甲状腺激素有助于早期发现甲状腺功能减退症，而血清三碘甲状腺原氨酸有助于迅速识别甲状腺功能亢进症的复发。
