MacLeod Jill E, Potter Alexandra S, Simoni Michael K, Bucci David J
Department of Psychological and Brain Sciences, Dartmouth College, 6207 Moore Hall, Hanover, NH 03755, USA.
Eur J Pharmacol. 2006 Dec 3;551(1-3):76-9. doi: 10.1016/j.ejphar.2006.08.082. Epub 2006 Sep 12.
The effect of nicotine on conditioned inhibition was examined using a serial feature negative discrimination task. Nicotine (0.35 mg/kg) or vehicle was administered before each of the 16 training sessions. On some trials in each session, a tone was presented and followed by food reward. On other trials, the tone was preceded by a visual stimulus and not reinforced. Nicotine-treated rats exhibited greater discrimination between the two trial types as evidenced by less frequent responding during non-reinforced trials, and learned the discrimination in fewer sessions than vehicle-treated rats. In contrast, there were no group differences in responding during the reinforced trials.
使用连续特征负性辨别任务来研究尼古丁对条件性抑制的影响。在16次训练中的每次训练前，给大鼠注射尼古丁（0.35毫克/千克）或赋形剂。在每次训练的一些试验中，呈现一个音调，随后给予食物奖励。在其他试验中，音调之前会有一个视觉刺激，且不给予强化。与注射赋形剂的大鼠相比，注射尼古丁的大鼠在非强化试验中的反应频率更低，这表明它们对两种试验类型的辨别能力更强，并且在更少的训练次数中就学会了这种辨别。相比之下，在强化试验中，两组大鼠的反应没有差异。
