Kitziger K J, Sanders W E, Andrews C P
Department of Orthopaedics, University of Texas Health Science Center, San Antonio.
J Hand Surg Am. 1990 Nov;15(6):902-5. doi: 10.1016/0363-5023(90)90012-g.
Low-molecular weight dextran is commonly used to prevent thrombosis after microvascular procedures; however, the potential complications of this drug are not well known. We report a case of acute pulmonary edema in a healthy person after elective microsurgery for treatment of a malignant tumor of the forearm. The mechanism of action of dextran and the pathophysiology of two potential adverse reactions to this drug are discussed. It is thought that in this patient pulmonary edema was caused by dextran toxicity.
低分子量右旋糖酐常用于预防微血管手术后的血栓形成；然而，这种药物的潜在并发症尚不清楚。我们报告了一例在择期显微手术后发生急性肺水肿的健康患者，该手术用于治疗前臂恶性肿瘤。本文讨论了右旋糖酐的作用机制以及该药物两种潜在不良反应的病理生理学。据认为，该患者的肺水肿是由右旋糖酐毒性引起的。
