大鼠前列腺外侧ZIP2信使核糖核酸表达与锌水平之间的相关性

Correlation between ZIP2 messenger RNA expression and zinc level in rat lateral prostate.

作者信息

Iguchi Kazuhiro, Otsuka Takashi, Usui Shigeyuki, Sugimura Yoshiki, Hirano Kazuyuki

机构信息

Laboratory of Pharmaceutics, Gifu Pharmaceutical University, Mitahora-higashi, Gifu, Gifu 502-8585, Japan.

出版信息

Biol Trace Elem Res. 2006 Aug;112(2):159-67. doi: 10.1385/BTER:112:2:159.

DOI:10.1385/BTER:112:2:159

PMID:17028381

Abstract

Zinc content in rat lateral prostate (LP) is higher compared with the other tissues, but the zinc retention system in the prostate remains unclear. In the present study, we examined the expression of ZRT, a IRT-like protein (ZIP) family transporter in rat prostate. The zinc level in rat LP was higher compared with the ventral (VP) and dorsal prostate (DP). The predicted ZIP2 mRNA was really expressed in LP at a high level. The expression was decreased in LP from castrated rats, associated with a decrease in zinc level, and these changes were prevented by testosterone replacement. Moreover, ZIP2 expression levels in LP positively correlated with the zinc levels. These findings strongly suggest that ZIP2 is involved in zinc homeostasis of rat prostate.

摘要

与其他组织相比，大鼠前列腺外侧叶（LP）中的锌含量更高，但前列腺中的锌保留系统仍不清楚。在本研究中，我们检测了大鼠前列腺中一种IRT样蛋白（ZIP）家族转运体ZRT的表达。与前列腺腹侧叶（VP）和背侧叶（DP）相比，大鼠LP中的锌水平更高。预测的ZIP2 mRNA在LP中确实高水平表达。去势大鼠LP中的表达降低，与锌水平降低相关，而睾酮替代可防止这些变化。此外，LP中ZIP2的表达水平与锌水平呈正相关。这些发现有力地表明ZIP2参与了大鼠前列腺的锌稳态。