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[老年病科医院内流感暴发:预防措施的有效性]

[Nosocomial influenza outbreak in a geriatrics department: Effectiveness of preventive measures].

作者信息

Andrieu Anne-Gaëlle, Paute Jocelyne, Glomot Laure, Jarlier Vincent, Belmin Joël

机构信息

Service de gériatrie, Hôpital Charles Foix et université Paris VI, Ivry-sur-Seine (94).

出版信息

Presse Med. 2006 Oct;35(10 Pt 1):1419-26. doi: 10.1016/s0755-4982(06)74830-8.

Abstract

OBJECTIVE

To describe a nosocomial influenza outbreak and the pharmacologic and nonpharmacologic control measures implemented in a hospital ward with beds for acute geriatric care and rehabilitation care.

METHODS

Descriptive survey conducted in the geriatrics department of a university hospital. An influenza outbreak occurred in February 2005 in 2 of the department's 3 separate units. The study concerned all patients in the 2 affected units (A and B) present during the outbreak, as well as all department staff. Once cases of influenza were confirmed, elderly patients in contact with influenza patients received chemoprophylaxis with oseltamivir when it became available.

RESULTS

Thirty-eight (76%) patients and 62 (38%) staff members had been vaccinated. The time from the initial symptoms of the first case until implementation of control measures was 7 days in unit A but only 1 day in unit B, -and chemoprophylaxis of contact patients began in 9 days and 24 hours respectively. The attack rate was 38% in the 38 vaccinated patients and 29% in the 14 unvaccinated patients (NS). All cases met the definition of nosocomial infection. No deaths imputable to influenza occurred during the outbreak. The implementation of the nonpharmacologic measures aimed at preventing spread of the outbreak presented no particular difficulty, except for compliance with geographic isolation of some patients with dementia and influenza. The difference between the attack rates for the two sectors (48% for unit A and 28% for unit B) suggests that the preventive measures were effective. Tolerance to chemoprophylaxis with oseltamivir was good.

CONCLUSION

This study confirmed that influenza can affect elderly hospital patients, even those in whom the vaccination rate is high, and that rapid detection of the outbreak and immediate implementation of pharmacologic and nonpharmacologic preventive measures can limit its spread.

摘要

目的

描述在一家设有急性老年护理和康复护理床位的医院病房中发生的医院内流感暴发情况以及所采取的药物和非药物控制措施。

方法

在一家大学医院的老年病科进行描述性调查。2005年2月,该科室3个独立单元中的2个发生了流感暴发。本研究涉及暴发期间在2个受影响单元(A和B)的所有患者以及所有科室工作人员。一旦确诊流感病例,与流感患者接触的老年患者在有奥司他韦时即接受化学预防。

结果

38名(76%)患者和62名(38%)工作人员接种了疫苗。从首例病例出现初始症状到实施控制措施的时间,A单元为7天,而B单元仅为1天,接触患者的化学预防分别在9天和24小时后开始。38名接种疫苗的患者中感染率为38%,14名未接种疫苗的患者中感染率为29%(无显著差异)。所有病例均符合医院感染的定义。暴发期间未发生可归因于流感的死亡病例。旨在防止暴发传播的非药物措施的实施没有特别困难,只是对一些患有痴呆症和流感的患者进行地理隔离时存在依从性问题。两个部门感染率的差异(A单元为48%,B单元为28%)表明预防措施是有效的。对奥司他韦化学预防的耐受性良好。

结论

本研究证实流感可影响老年住院患者,即使是那些疫苗接种率高的患者,并且快速检测暴发并立即实施药物和非药物预防措施可限制其传播。

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