使用加利福尼亚言语学习测验对多发性硬化症患者情景记忆的研究：数据支持编码改变
[Study of episodic memory in multiple sclerosis using the California Verbal Learning Test: the data favour altered encoding].
作者信息
Defer G L, Daniel F, Marié R M
机构信息
UPRES-EA 3917, Service de Neurologie Déjerine, CHU de Caen, 14033 Cedex.
出版信息
Rev Neurol (Paris). 2006 Sep;162(8-9):852-7. doi: 10.1016/s0035-3787(06)75089-5.
INTRODUCTION
Alteration of episodic memory is one of the main cognitive deficits observed in MS patients.
PATIENTS AND METHODS
We studied episodic memory in a group of 71 MS patients (37 RR, 34 SP) with the California Verbal Learning test (CVLT). Direct scores and calculated indices from CVLT performances were analyzed in comparison with controls.
RESULTS
We observed a deficit of episodic memory in 69 p.cent of patients. This deficit was related to an alteration of encoding and retrieval processes. Despite SP-MS patients performances were constantly lower than those of RR-MS patients no significant difference was observed between the two groups. Significant correlation between the disease duration and CVLT performances were observed for the whole group but not for RR- or SP-MS groups separately, indicating that duration is more important than the phase of the disease in the worsening of memory deficit.
引言
情景记忆改变是多发性硬化症（MS）患者中观察到的主要认知缺陷之一。
患者与方法
我们使用加利福尼亚言语学习测试（CVLT）对一组71例MS患者（37例复发缓解型，34例继发进展型）的情景记忆进行了研究。将CVLT表现的直接得分和计算出的指标与对照组进行比较分析。
结果
我们观察到69%的患者存在情景记忆缺陷。这种缺陷与编码和检索过程的改变有关。尽管继发进展型MS患者的表现始终低于复发缓解型MS患者，但两组之间未观察到显著差异。在整个研究组中观察到病程与CVLT表现之间存在显著相关性，但在复发缓解型或继发进展型MS组中分别未观察到，这表明在记忆缺陷恶化方面，病程比疾病阶段更重要。
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