Semmler M P, Driemel O, Staudenmaier R, Froelich K, Kleinsasser N H
Universität Ulm, Universitätsklinik und Hochschulambulanz für Hals-, Nasen-, Ohrenheilkunde, Ulm, Germany.
Mund Kiefer Gesichtschir. 2006 Nov;10(6):395-401. doi: 10.1007/s10006-006-0025-5.
Tumorigenesis is based on initiation, promotion, and progression, whereas tobacco smoke is a decisive predisposing factor for squamous cell carcinomas of the upper aerodigestive tract. A variety of tobacco smoke compounds is known to potentially initiate tumors, but the alkaloid nicotine is generally considered to induce addiction only. However, there is growing evidence that nicotine may also contribute to early stages of tumorigenesis. In the present study, a possible direct genotoxic potential of nicotine is investigated.
Lymphatic tissue of the tonsilla palatina of eight donors was harvested during surgery and incubated with nicotine. DNA damage was measured with the comet assay.
Genotoxic effects of nicotine could be demonstrated.
The results suggest a direct contribution of nicotine to tumor initiation and carcinogenesis.
肿瘤发生基于起始、促进和进展，而烟草烟雾是上呼吸道消化道鳞状细胞癌的决定性诱发因素。已知多种烟草烟雾化合物可能引发肿瘤，但生物碱尼古丁通常仅被认为会导致成瘾。然而，越来越多的证据表明尼古丁也可能促成肿瘤发生的早期阶段。在本研究中，对尼古丁可能的直接遗传毒性潜力进行了研究。
在手术过程中采集了八位捐赠者腭扁桃体的淋巴组织，并与尼古丁一起孵育。用彗星试验测量DNA损伤。
可证明尼古丁具有遗传毒性作用。
结果表明尼古丁对肿瘤起始和致癌作用有直接影响。
