Schreiber S L
Harvard University, Cambridge, MA 02138.
Science. 1991 Jan 18;251(4991):283-7. doi: 10.1126/science.1702904.
Cyclosporin A, FK506, and rapamycin are inhibitors of specific signal transduction pathways that lead to T lymphocyte activation. These immunosuppressive agents bind with high affinity to cytoplasmic receptors termed immunophilins (immunosuppressant binding proteins). Studies in this area have focused on the structural basis for the molecular recognition of immunosuppressants by immunophilins and the biological consequences of their interactions. Defining the biological roles of this emerging family of receptors and their ligands may illuminate the process of protein trafficking in cells and the mechanisms of signal transmission through the cytoplasm.
环孢素A、FK506和雷帕霉素是导致T淋巴细胞活化的特定信号转导途径的抑制剂。这些免疫抑制剂与称为亲免素（免疫抑制剂结合蛋白）的细胞质受体具有高亲和力结合。该领域的研究集中在亲免素对免疫抑制剂分子识别的结构基础及其相互作用的生物学后果。确定这个新兴受体家族及其配体的生物学作用可能会阐明细胞中蛋白质运输的过程以及通过细胞质进行信号传导的机制。
