Guan Guo-dong, Xu En, Wang Xiao-juan, Xu Yin-hong, Qiu Shao-dong
Department of Neurology, the Second Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong, 510260 PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Oct;23(5):519-22.
To investigate the relationship between lipoprotein lipase (LPL) gene Ser447Ter polymorphism and atherosclerotic cerebral infarction (CI), and to investigate the effect of Ser447Ter polymorphism on plasma lipids, carotid intima-media thickness (IMT) and carotid artery plaque (CAP) in patients with CI.
PCR-restriction fragment lengh polymorphism (PCR-RFLP) technique was used to detect LPL gene Ser447Ter polymorphism in 166 patients with CI (CI group) and 72 healthy subjects (control group). Carotid IMT and CAP were measured with carotid color ultrasonographic doppler for the patients and the controls.
CG+GG carriers had lower plasma triglyceride (TG) levels and higher high density lipoprotein cholesterol (HDL-C) levels than CC carriers in CI group (P=0.001 and P=0.007 respectively). CG+GG carriers had lower plasma TG levels than CC carriers in control group (P=0.041). The frequency of G allele in CI patients was significantly lower than that in control subjects (P= 0.014). There was no statistical correlation between LPL Ser447Ter gene polymorphism and carotid IMT and CAP.
The Ser447Terls polymorphism of LPL gene is significantly associated with plasma lipids and CI. G allele genotype may lead to decrease of plasma TG and increase of plasma HDL-C. G allele may be a protective genotype of CI.
探讨脂蛋白脂肪酶（LPL）基因Ser447Ter多态性与动脉粥样硬化性脑梗死（CI）的关系，以及Ser447Ter多态性对CI患者血脂、颈动脉内膜中层厚度（IMT）和颈动脉斑块（CAP）的影响。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术检测166例CI患者（CI组）和72例健康对照者（对照组）的LPL基因Ser447Ter多态性。对患者和对照者采用颈动脉彩色超声多普勒测量颈动脉IMT和CAP。
CI组中，CG+GG携带者的血浆甘油三酯（TG）水平低于CC携带者，高密度脂蛋白胆固醇（HDL-C）水平高于CC携带者（分别为P=0.001和P=0.007）。对照组中，CG+GG携带者的血浆TG水平低于CC携带者（P=0.041）。CI患者中G等位基因频率显著低于对照者（P=0.014）。LPL Ser447Ter基因多态性与颈动脉IMT和CAP之间无统计学相关性。
LPL基因的Ser447Ter多态性与血脂及CI显著相关。G等位基因基因型可能导致血浆TG降低和血浆HDL-C升高。G等位基因可能是CI的一种保护性基因型。
