Porritt Michelle J, Kingsbury Ann E, Hughes Andrew J, Howells David W
Austin Health, Department of Medicine, University of Melbourne, Victoria, Australia.
Mov Disord. 2006 Dec;21(12):2208-11. doi: 10.1002/mds.21129.
Increased numbers of dopaminergic neurons are described in the striatum of patients with Parkinson's disease. In postmortem striatal tissue from Parkinson's disease patients with short disease duration (< or =8 years), the number of dopaminergic neurons is approximately four times that in patients with long duration (> or =16 years). The data suggest the possibility that the presence of large numbers of these striatal dopaminergic neurons may be harmful and may accelerate the disease process. Alternatively, these neurons may be lost to the disease process.
帕金森病患者纹状体中多巴胺能神经元数量增加。在病程较短（≤8年）的帕金森病患者的死后纹状体组织中，多巴胺能神经元数量约为病程较长（≥16年）患者的四倍。这些数据表明，大量这些纹状体多巴胺能神经元的存在可能有害，并可能加速疾病进程。或者，这些神经元可能在疾病过程中丢失。
