Fu Yuan, Ito Mikako, Fujita Yasunori, Ito Masafumi, Ichihara Masatoshi, Masuda Akio, Suzuki Yumi, Maesawa Satoshi, Kajita Yasukazu, Hirayama Masaaki, Ohsawa Ikuroh, Ohta Shigeo, Ohno Kinji
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Neurosci Lett. 2009 Apr 3;453(2):81-5. doi: 10.1016/j.neulet.2009.02.016. Epub 2009 Feb 12.
Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but not the other reactive oxygen and nitrogen species. In the past year, molecular hydrogen has been reported to prevent or ameliorate eight diseases in rodents and one in human associated with oxidative stress. In Parkinson's disease, mitochondrial dysfunction and the associated oxidative stress are major causes of dopaminergic cell loss in the substantia nigra. We examined effects of approximately 50%-saturated molecular hydrogen in drinking water before or after the stereotactic surgery on 6-hydroxydopamine-induced nigrostrital degeneration in a rat model of Parkinson's disease. Methamphetamine-induced behavioral analysis showed that molecular hydrogen prevented both the development and progression of the nigrostrital degeneration. Tyrosine hydroxylase staining of the substantia nigra and striatum also demonstrated that pre- and post-treatment with hydrogen prevented the dopaminergic cell loss. Our studies suggest that hydrogen water is likely able to retard the development and progression of Parkinson's disease.
分子氢作为一种抗氧化剂，可减少羟基自由基，但对其他活性氧和氮物种无效。在过去一年中，据报道分子氢可预防或改善啮齿动物的八种疾病以及人类的一种与氧化应激相关的疾病。在帕金森病中，线粒体功能障碍及相关的氧化应激是黑质中多巴胺能细胞丢失的主要原因。我们在立体定向手术前后，研究了饮用水中约50%饱和的分子氢对帕金森病大鼠模型中6-羟基多巴胺诱导的黑质纹状体变性的影响。甲基苯丙胺诱导的行为分析表明，分子氢可预防黑质纹状体变性的发生和进展。黑质和纹状体的酪氨酸羟化酶染色也表明，氢气预处理和后处理均可防止多巴胺能细胞丢失。我们的研究表明，氢水可能能够延缓帕金森病的发生和进展。
