Kurz Martin Wilhelm, Larsen Jan Petter, Kvaloy Jan Terje, Aarsland Dag
Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany.
Mov Disord. 2006 Dec;21(12):2170-4. doi: 10.1002/mds.21144.
Dementia is common in patients with Parkinson's disease (PDD). The etiology of PDD is still unclear, but exciting advances have been made in discovering pathogenetic components in Parkinson's disease (PD), implicating the role of genetic factors. It is, however, still controversial whether genetic factors also contribute to the development of dementia in PD. Thus, we investigated the association between development of dementia and a positive family history of PD or dementia in a community-based study of PD in Rogaland County, Norway (n = 219). The patients were followed prospectively with neurological and neuropsychological assessments. Dementia was more common in patients with a strong family association of PD (first-degree relatives > second-degree relatives > no family history; P < 0.05). However, time to dementia did not differ between the two groups. No associations between dementia in PD and familial occurrence of dementia could be shown. Further studies with larger samples are needed to explore a possible relationship between a family history of PD and development of dementia in PD and its potential pathogenetic mechanisms.
痴呆在帕金森病（PDD）患者中很常见。PDD的病因仍不清楚，但在发现帕金森病（PD）的致病因素方面已经取得了令人兴奋的进展，这暗示了遗传因素的作用。然而，遗传因素是否也促成了PD患者痴呆的发生仍存在争议。因此，我们在挪威罗加兰郡开展了一项基于社区的PD研究（n = 219），调查痴呆的发生与PD或痴呆的阳性家族史之间的关联。对患者进行前瞻性的神经学和神经心理学评估。在有强烈PD家族关联的患者中，痴呆更为常见（一级亲属>二级亲属>无家族史；P < 0.05）。然而，两组患者出现痴呆的时间没有差异。未发现PD患者的痴呆与家族性痴呆发生之间存在关联。需要进行更大样本量的进一步研究，以探索PD家族史与PD患者痴呆发生之间可能的关系及其潜在的致病机制。
