Janvin Carmen Cristea, Aarsland Dag, Larsen Jan Petter
Department for Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway.
J Geriatr Psychiatry Neurol. 2005 Sep;18(3):149-54. doi: 10.1177/0891988705277540.
Although mild cognitive impairment and dementia are common and have important clinical consequences for patients with Parkinson's disease (PD) and their caregivers, it is still unclear whether cognitive symptoms may predict the development of dementia in PD patients. The objective of this study was to determine whether cognitive deficits in nondemented PD patients predicted the development of dementia 4 years later. A total of 76 nondemented PD patients from an epidemiological study of PD in the county of Rogaland, Norway, were assessed at baseline and 4 years later with neurological, psychiatric, and neuropsychological evaluations. Twenty-five (42%) new cases of dementia were diagnosed after 4 years. Time to complete the third card of the Stroop test was the only variable that was independently associated with dementia. The authors concluded that poor performance on a test sensitive to executive dysfunction predicted later development of dementia in PD patients. This finding may have important clinical implications as a marker of subsequent development of dementia.
尽管轻度认知障碍和痴呆很常见，且对帕金森病（PD）患者及其照料者具有重要的临床影响，但认知症状是否能预测PD患者痴呆的发生仍不清楚。本研究的目的是确定非痴呆PD患者的认知缺陷是否能预测4年后痴呆的发生。对挪威罗加兰郡一项PD流行病学研究中的76例非痴呆PD患者在基线时和4年后进行了神经学、精神病学和神经心理学评估。4年后诊断出25例（42%）新的痴呆病例。完成Stroop测试第三张卡片的时间是唯一与痴呆独立相关的变量。作者得出结论，对执行功能障碍敏感的测试表现不佳可预测PD患者日后痴呆的发生。这一发现作为痴呆后续发展的标志物可能具有重要的临床意义。
