Micci Maria-Adelaide, Pasricha Pankaj Jay
Enteric Neuromuscular Disorders and Pain Laboratory, Division of Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas 77555-0764, USA.
Dev Dyn. 2007 Jan;236(1):33-43. doi: 10.1002/dvdy.20975.
The main goal of this review is to summarize the status of the research in the field of stem cells transplantation, as it is applicable to the treatment of gastrointestinal motility. This field of research has advanced tremendously in the past 10 years, and recent data produced in our laboratories as well as others is contributing to the excitement on the use of neural stem cells (NSC) as a valuable therapeutic approach for disorders of the enteric nervous system characterized by a loss of critical neuronal subpopulations. There are several sources of NSC, and here we describe therapeutic strategies for NSC transplantation in the gut. These include using NSC as a relatively nonspecific cellular replacement strategy in conditions where large populations of neurons or their subsets are missing or destroyed. As with many other recent "breakthroughs" stem cell therapy may eventually prove to be overrated. However, at the present time, it does appear to provide the hope for a true cure for many currently intractable diseases of both the central and the peripheral nervous system. Certainly more extensive research is needed in this field. We hope that our review will encourage new investigators in entering this field of research ad contribute to our knowledge of the potentials of NSC and other cells for the treatment of gastrointestinal dysmotility.
本综述的主要目的是总结干细胞移植领域的研究现状，因为其适用于胃肠动力障碍的治疗。在过去十年中，该研究领域取得了巨大进展，我们实验室以及其他实验室最近产生的数据，让人们对使用神经干细胞（NSC）作为治疗肠神经系统疾病的一种有价值的治疗方法感到兴奋，这些疾病的特征是关键神经元亚群缺失。神经干细胞有多种来源，在此我们描述在肠道中进行神经干细胞移植的治疗策略。这些策略包括在大量神经元或其亚群缺失或被破坏的情况下，将神经干细胞用作一种相对非特异性的细胞替代策略。与许多其他近期的“突破”一样，干细胞疗法最终可能被证明是被高估了。然而，目前它似乎确实为治愈许多目前难以治疗的中枢和外周神经系统疾病带来了希望。当然，该领域还需要更广泛的研究。我们希望我们的综述将鼓励新的研究人员进入这个研究领域，并有助于我们了解神经干细胞和其他细胞治疗胃肠动力障碍的潜力。
