Uhl Idun, Gorynia Inge, Gallinat Jürgen, Mulert Christoph, Wutzler Alexander, Heinz Andreas, Juckel Georg
Department of Psychiatry and Psychotherapy, Charité, Campus Mitte, Berlin, Germany.
Hum Psychopharmacol. 2006 Oct;21(7):463-71. doi: 10.1002/hup.803.
The loudness dependence of auditory evoked potentials (LDAEP) has been discussed as a non-invasive in vivo marker of central serotonergic function. Evidence for this has been found in animal studies, but studies in humans provide less consistent results. In this study, the relationship between LDAEP and directly modulated central serotonergic activity in healthy subjects was investigated. In a single-blind cross-over design, the LDAEP of female participants (age: 24.0 +/- 2.3 years) was measured under two conditions: (1) infusion of 20 mg citalopram diluted in 250 ml 0.9% saline and (2) infusion of 250 ml 0.9% saline as placebo. LDAEP was measured at five different time points before, during and up to 60 min after drug/placebo administration and dipole source analysis was performed. The increase of the central serotonin activity in response to citalopram was not accompanied by a significant change of the LDAEP compared to the placebo condition. The result underlines that the acceptance of LDAEP as a marker of central serotonergic function still needs further discussion.
听觉诱发电位的响度依赖性（LDAEP）已被讨论作为中枢5-羟色胺能功能的一种非侵入性体内标志物。动物研究已找到相关证据，但人体研究结果却不太一致。在本研究中，对健康受试者LDAEP与直接调节的中枢5-羟色胺能活性之间的关系进行了调查。在单盲交叉设计中，对女性参与者（年龄：24.0±2.3岁）在两种条件下测量其LDAEP：（1）输注稀释于250ml 0.9%盐水中的20mg西酞普兰，（2）输注250ml 0.9%盐水作为安慰剂。在给药/安慰剂前、给药期间及给药后长达60分钟的五个不同时间点测量LDAEP，并进行偶极子源分析。与安慰剂组相比，西酞普兰引起的中枢5-羟色胺活性增加并未伴随LDAEP的显著变化。该结果强调，将LDAEP作为中枢5-羟色胺能功能标志物仍需进一步探讨。
