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听觉诱发电位的响度依赖性（LDAEP）与健康志愿者中多巴胺转运体和 5-羟色胺转运体的可用性相关——一项使用两种同位素 SPECT 的研究。

Loudness dependence of auditory evoked potentials (LDAEP) correlates with the availability of dopamine transporters and serotonin transporters in healthy volunteers-a two isotopes SPECT study.

机构信息

Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, 70428, Taiwan, Republic of China.

出版信息

Psychopharmacology (Berl). 2011 Apr;214(3):617-24. doi: 10.1007/s00213-010-2064-8. Epub 2010 Nov 12.

DOI:10.1007/s00213-010-2064-8
PMID:21072504
Abstract

RATIONALE AND OBJECTIVE

Although loudness dependence of auditory evoked potentials (LDAEPs) had been suggested as a noninvasive measure of central serotonin functions, recent studies suggest that LDAEP may be modulated by multiple neuromodulatory systems, such as dopamine. Here, we explore the relationship between LDAEP and dopamine and serotonin in the level of monoamine transporter availability.

METHODS

Forty-nine healthy volunteers received LDAEP and single-photon emission computed tomography (SPECT) using [(99m)Tc] TRODAT and [(123)I] ADAM to approximate the availability of dopamine transporters (DATs) and serotonin transporters (SERTs).

RESULTS

LDAEP was found to be positively associated with DAT, after adjusting for age and gender, and the log-transformed slope of loudness dependence at Cz was negatively associated with SERT.

CONCLUSION

Our findings provide further evidence for the possible involvement of dopamine and serotonins in the genesis of LDAEP.

摘要

原理与目的

虽然听觉诱发电位的响度依赖性（LDAEPs）已被认为是一种非侵入性的中枢 5-羟色胺功能测量方法，但最近的研究表明，LDAEP 可能受到多种神经调质系统的调制，如多巴胺。在这里，我们探讨了 LDAEP 与多巴胺和 5-羟色胺在单胺转运体可用性水平上的关系。

方法

49 名健康志愿者接受了 LDAEP 和单光子发射计算机断层扫描（SPECT），使用 [(99m)Tc] TRODAT 和 [(123)I] ADAM 来近似多巴胺转运体（DATs）和 5-羟色胺转运体（SERTs）的可用性。

结果

在调整年龄和性别后，发现 LDAEP 与 DAT 呈正相关，而 Cz 处的响度依赖性的对数斜率与 SERT 呈负相关。

结论

我们的发现为多巴胺和 5-羟色胺可能参与 LDAEP 的产生提供了进一步的证据。

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