Schlathölter Thomas, Alvarado Fresia, Bari Sadia, Lecointre Aurelie, Hoekstra Ronnie, Bernigaud Virgil, Manil Bruno, Rangama Jimmy, Huber Bernd
KVI Atomic Physics, Rijksuniversiteit Groningen, Zernikelaan 25, 9747AA Groningen, The Netherlands.
Chemphyschem. 2006 Nov 13;7(11):2339-45. doi: 10.1002/cphc.200600361.
A large number of studies are devoted to the investigation of the biomolecular ionization and fragmentation dynamics underlying biological radiation damage. Most of these studies have been based on gas-phase collisions with isolated DNA building blocks. The radiobiological significance of these studies is often questioned because of the lack of a chemical environment. To clarify this aspect, we studied interactions of keV ions with isolated nucleobases and with nucleobase clusters by means of coincidence time-of-flight spectrometry. Significant changes already show up in the molecular fragmentation patterns of very small clusters.
大量研究致力于探究生物辐射损伤背后的生物分子电离和碎片化动力学。这些研究大多基于与分离的DNA构建模块的气相碰撞。由于缺乏化学环境，这些研究的放射生物学意义常常受到质疑。为了阐明这一方面，我们通过符合飞行时间光谱法研究了keV离子与分离的核碱基以及核碱基簇的相互作用。在非常小的簇的分子碎片化模式中已经出现了显著变化。
