Mindea Stefan A, Yang Benson P, Bendok Bernard R, Miller Jeffrey W, Batjer H Hunt
Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Neurosurg Focus. 2006 Sep 15;21(3):E13. doi: 10.3171/foc.2006.21.3.13.
Cerebral vasospasm is a significant cause of morbidity and mortality in patients who have sustained a subarachnoid hemorrhage from aneurysm rupture. Symptomatic cerebral vasospasm is also a strong predictor of poor clinical outcome and has thus drawn a great deal of interest from cerebrovascular surgeons. Although medical management is the cornerstone of treatment for this condition, endovascular intervention may be warranted for those in whom this treatment fails and in whom symptomatic vasospasm subsequently develops. The rapid advancements in endovascular techniques and pharmacological agents used to combat this pathological state continue to offer promise in broadening the available treatment armamentarium. In this article the authors discuss the rationale and basis for using the various endovascular options for the treatment of cerebral vasospasm, and they also discuss the limitations, complications, and efficacy of these treatment strategies in regard to neurological condition and outcome.
对于因动脉瘤破裂导致蛛网膜下腔出血的患者,脑血管痉挛是发病和死亡的重要原因。有症状的脑血管痉挛也是临床预后不良的有力预测指标,因此引起了脑血管外科医生的极大兴趣。尽管药物治疗是这种疾病治疗的基石,但对于那些药物治疗失败且随后出现有症状血管痉挛的患者,可能需要进行血管内介入治疗。用于对抗这种病理状态的血管内技术和药物的快速发展,在拓宽可用治疗手段方面继续带来希望。在本文中,作者讨论了使用各种血管内治疗方法治疗脑血管痉挛的基本原理和依据,还讨论了这些治疗策略在神经状况和预后方面的局限性、并发症及疗效。