Ferrario Carrie R, Robinson Terry E
Department of Psychology (Biopsychology), The University of Michigan, 530 Church Street, Ann Arbor, MI 48109-1304, USA.
Eur Neuropsychopharmacol. 2007 Apr;17(5):352-7. doi: 10.1016/j.euroneuro.2006.08.005. Epub 2006 Oct 6.
It has been proposed that some neuroadaptations that underlie behavioral sensitization may play a role in the development and persistence of addiction. However, whether or not sensitization facilitates the development of symptoms specific to addiction, such as the escalation of drug intake, is not known. We examined, therefore, the effect of pretreatment with a sensitizing regimen of amphetamine on the escalation of subsequent drug intake in rats given the opportunity to self-administer cocaine. Amphetamine pretreatment produced psychomotor sensitization and also accelerated the subsequent escalation of cocaine intake. This suggests that the neural circuits that are altered as a consequence of repeated amphetamine treatment, and the induction of sensitization, may overlap with those responsible for the development of some addiction-like behaviors.
有人提出，一些作为行为敏化基础的神经适应性变化可能在成瘾的发展和持续过程中起作用。然而，敏化是否促进成瘾特有的症状发展，如药物摄入量的增加，尚不清楚。因此，我们研究了用苯丙胺敏化方案预处理对有机会自行注射可卡因的大鼠随后药物摄入量增加的影响。苯丙胺预处理产生了精神运动性敏化，并且还加速了随后可卡因摄入量的增加。这表明，由于反复给予苯丙胺治疗以及敏化的诱导而改变的神经回路，可能与那些导致某些成瘾样行为发展的神经回路重叠。
